Episode 67:  Longevity: What we know and what we need to know about living longer and better


Episode Summary:

In this episode, we explore our understanding of longevity with a leading longevity researcher.


Dr Matt Kaeberlein, PhD

Former Director, Healthy Aging and Longevity Research Institute

Former Director, Biological Mechanisms of Healthy Aging Training Program

Co-Director, UW Nathan Shock Center of Excellence in the Basic Biology of Aging

Co-Director, Dog Aging Project

Professor of Pathology

Adjunct Professor of Genome Sciences

Adjunct Professor of Oral Health Sciences

Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA).  Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Former Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.

During This Episode, We Discuss:

The Dog Aging Project

What makes us age?

What are the hallmarks of aging?

What we know about longevity determinants. Genetics or Environment or both?

Are there longevity genes?

What role do diet, exercise, and maintenance of muscle mass/ strength, play in longevity

What do we know about successful cultures that live longer

What research is exciting and ongoing? What we still need to understand.

Dr. Kaeberlein’s thoughts on:

Longevity Clinics


Growth Hormone

Calorie Restriction

Medications (Growth Hormone, Metformin, Rapamycin)

Other Longevity Researchers, Practitioners …


“ Updated hallmarks of aging, (11 or 12 depending on who you talk to), these are types of cellular dysfunction and damage that happen with age across all animals and are directly contributing to our increased risk of developing diseases of old age, developing functional decline”…    

                                                                                                             Dr. Matt Kaeberlein

“There are all these functional declines that go along with the aging process that from a quality of life perspective that I would argue of equally if not more important than the actual overt diseases”

                                                                                                              Dr. Matt Kaeberlein

Recommended Resources:

Twitter @mkaeberlein

Peter Attia: Podcast, book, articles

Episode Transcript:

Coming soon!

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